Among them, ERBB2, MAP3K8, ABCB1, IL1B, MTOR, DPP4, IFNG, CYP1B1, NQO1, PAM were risk factors (odds ratio > 1), while serum/glucocorticoid-regulated kinase 1 (SGK1), epidermal growth factor (EGF), HSD17B3, LDHA, ENPP1 were protective factors (odds ratio < 1) for BPH (Supplementary Material 1, Supplemental Digital Content, https://links.lww.com/MD/Q552). The gene discussed is EGF; the disease is benign prostatic hyperplasia.