As a key regulator of inflammatory signaling, SGK1 may exacerbate this process by activating the NF-κB pathway, promoting the nuclear translocation of NF-κB, and enhancing the transcription of pro-inflammatory cytokines, thereby facilitating the development of BPH.[71,72] The results of this study further confirm that SGK1 is significantly enriched in the TNF-α-mediated NF-κB signaling pathway, reinforcing its critical role in this pathway. The gene discussed is TNF; the disease is benign prostatic hyperplasia.