Sensitivity analysis showed that the MR analysis of the 12 genes (ABCB1, MAP3K8, IFNG, SGK1, IL1B, HSD17B3, LDHA, CYP1B1, EGF, NQO1, ENPP1, MTOR) were reliable, and they were potential biomarkers for BPH (Supplementary Material 4, Supplemental Digital Content, https://links.lww.com/MD/Q553). This evidence concerns the gene HSD17B3 and benign prostatic hyperplasia.