Specifically, ADAM9, as a membrane-bound metalloproteinase, not only participates in inflammatory responses by promoting monocyte-macrophage fusion (P < .05), but its expression level also shows a significant positive correlation with activated dendritic cell infiltration (r = 0.35, P = .008), suggesting its potential regulatory role in immune cell activation during sepsis. The gene discussed is ADAM9; the disease is Sepsis.