Previous studies have shown that upregulation of TGFA can activate the EGFR signaling pathway to inhibit LCN2 expression, ultimately promoting epithelial cell proliferation.[43] Similarly, in sepsis, TGFA may disrupt immune balance by overactivating the EGFR signaling pathway, leading to abnormal cell proliferation responses that influence disease progression. This evidence concerns the gene LCN2 and Sepsis.