This differential recognition pattern provides potential insights for studying the heterogeneous immune responses in pediatric sepsis.[32] Similar to the central role of TLRs in immune recognition and inflammatory regulation, ADAM9, as a crucial extracellular matrix metalloproteinase, participates in inflammatory responses by regulating monocyte-macrophage transformation.[29] These 2 proteins exhibit functional overlap and complementarity in critical aspects such as initiating inflammatory responses, recruiting immune cells, and recognizing and responding to pathogens. The gene discussed is ADAM9; the disease is Sepsis.