In sepsis, the expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, a key enzyme in postinfectious glycolysis, can be attenuated by inhibition of p38 in the MAPK signaling pathway to reduce the development of sepsis.[28]. This evidence concerns the gene PFKFB3 and Sepsis.