Elevated cytokine storm markers, including CRP, IL-6, and IL-10, have been linked to worsening COVID-19 cases.[31] Treatment with anti-IL-17 therapy has been shown to alleviate inflammation and improve oxygenation in hospitalized patients with severe COVID-19.[32] However, there has been a lack of research focusing on the impact of previous severe COVID-19 history on the expression of inflammatory factors in sepsis patients. This evidence concerns the gene CRP and COVID-19.