CD38 is a NAD+-consuming enzyme that is upregulated in various tumor immunosuppressive environments, facilitating immune evasion.[50] Meanwhile, C7-DC is involved in mitochondrial fatty acid β-oxidation, and its elevation may reflect a state of metabolic reprogramming that supports the energy demands and biosynthetic precursors required by rapidly proliferating tumor cells.[51] Our findings suggest that CD38-high B cells may promote tumor-associated metabolic adaptation through regulation of lipid metabolism. Here, CD38 is linked to neoplasm.