In summary, we have established a gene-metabolite network that can affect the development of AD: PLTP, which can directly influence the diameter of AD, is closely connected to APOE through atorvastatin and SM, while APOE can not only directly regulate the formation and development of AD and the proliferation of VSMCs, but also regulate the metabolites cholesterol esters and triglycerides, further controlling the cell cycle and apoptosis of aortic VSMCs, increasing the number and development of aortic VSMCs, and thus affecting the development of AD. Here, APOE is linked to Alzheimer disease.