In mice, APOE deficiency can promote the release of inflammatory cytokines (such as IL-6, IL-1β, and MCP-1), increase the inflammatory response in the vascular wall, increase VSMC apoptosis, and promote the formation and development of AD, leading to the destruction of the aortic wall structure and the formation of abdominal AD.[34] At the same time, APOE has multiple effects on VSMCs. This evidence concerns the gene CCL2 and Alzheimer disease.