Additionally, using 2 human gene expression datasets (GSE190635/GSE202047, 12 AD patients, 4 healthy controls), we found that APOE and PLTP (genes identified as AD regulators in mice) predict human AD status with AUC values up to 0.989 in training and 0.897 in testing (Fig. 6A and B), directly linking preclinical gene targets to human disease relevance. Here, PLTP is linked to Alzheimer disease.