Using the same mouse model of aging, we also reported on the capacity of 4 weeks of Epi treatment (1 mg/kg/day) to significantly mitigate hippocampus OS, inflammation markers such as cytokines, hyperphosphorylation of tau protein, soluble β-amyloid protein levels while improving multiple cell survival linked endpoints, memory, anxiety-like behavior levels and systemic inflammation. The gene discussed is MAPT; the disease is Anxiety.