The European Academy of Allergy and Clinical Immunology (EAACI) has published three position papers on complex and controversial topics in non-IgE-mediated allergy: the diagnosis and management of non-IgE-mediated food allergies in breastfed infants, food protein-associated gastroesophageal reflux disease (GERD) and constipation [11,12,13]. This evidence concerns the gene IGHE and Allergy.