CASP8 and colonic neoplasm: Saber et al. [142] studied the anticancer activity of P. kudriavzevii AS-12 secretion metabolites against human colorectal cancer cell lines (HT-29 and Caco-2) and reported that methanolic extract of P. kudriavzevii AS-12 supernatant significantly inhibited proliferation and induced apoptosis through an increase (BAD, CASP-3, CASP-8, CASP-9, and Fas-R) or decrease (Bcl-2) in expression level of pro-/anti-apoptotic genes in the human colon cancer cells (HT-29 and Caco-2).