The classical model using a VD analog (calcipotriol/MC903) involves inducing an “AD-like” phenotype in mice (eosinophilic infiltration, type 2 immune dominance, and pruritus), mainly through the induction of TSLP (thymic stromal lymphopoietin) in keratinocytes, highlighting that excessive local VDR activation may initiate inflammation [108,109,110,111,112]. This evidence concerns the gene VDR and Alzheimer disease.