Further, the ginsenoside Rh4, a type of saponin found in ginseng—Panax ginseng and Panax notoginseng—has demonstrated significant inhibitory effects on CRC development in mice by promoting the growth of Akkermansia muciniphila, a commensal bacterium known to modulate the TLR4–NF-κB inflammatory signaling pathway. Here, NFKB1 is linked to colorectal carcinoma.