CASP3 and colorectal carcinoma: Similarly, ginsenosides—the principal active compounds in ginseng—such as 20R-Rg3 and Rg5-BG, have been reported to induce apoptosis in CRC cells through activation of the caspase-3/Bax/Bcl-2 signaling pathway, an effect closely associated with microbiota modulation [26].