Further, the ginsenoside Rh4, a type of saponin found in ginseng—Panax ginseng and Panax notoginseng—has demonstrated significant inhibitory effects on CRC development in mice by promoting the growth of Akkermansia muciniphila, a commensal bacterium known to modulate the TLR4–NF-κB inflammatory signaling pathway. The gene discussed is TLR4; the disease is colorectal carcinoma.