CRY1 and obesity due to melanocortin 4 receptor deficiency: For instance, Cry1 inactivation has been shown to reduce adipogenesis in mouse adipocytes [53], whereas Cry1-deficient mice show a relative resistance to obesity induced by a high-fat diet, results that were not observed in STD diet-fed animals, highlighting the critical role of the Cry1 gene under obesogenic conditions [54].