In line with inflammatory markers, the EMIKETO study (RCT in patients with migraine and overweight/obesity) observed decreases in CRP with a very low-calorie ketogenic diet (VLCKD) in a controlled setting [33], and a recent meta-analysis of randomized studies reported a significant reduction in CRP (with a non-significant downward trend in IL-6) in adults with overweight/obesity on ketogenic diets [34]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.