For example, in Bazzano’s RCT (12 months; adults with obesity), the reduction in (hs-)CRP was greater with a low-carbohydrate diet than with a low-fat diet (between-group Δ = −15.2 nmol/L; 95% CI: −27.6 to −1.9; p = 0.024; ≈ −1.75 mg/L) [69]. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.