RIGI and infection: However, these phenomena can be reconciled as follows: (i) transcriptional priming of RIG-I does not necessarily equate to broad inflammatory cytokine release in the absence of viral PAMPs; (ii) the effects of phytochemicals are stimulus- and time-dependent; and (iii) modulation of upstream sensors may coexist with an overall attenuation of pathological cytokine amplification during infection.