In the study by Ruan et al. [26], adipocytes and triple-negative breast cancer cells demonstrated mutual activation through the CXCL1/IL-6-mediated STAT3/NF-κB p65 pathway, where elevated phosphorylation of both STAT3 and NF-κB p65 provided direct experimental evidence for pathway activation. This evidence concerns the gene NFKB1 and triple-negative breast carcinoma.