This observation is notable, as it suggests that lower ZPR1 expression in HPV-positive cancers might make ZPR1 more available for recruitment by E2, rather than tightly coupled to SETX; however, because E2 levels in these tumors are unclear and this finding is based on observational transcriptomic data, not proteomics, further studies will be required to determine functional significance. The gene discussed is ZPR1; the disease is cancer.