The combined presence of genotypes HLA-F7:0976GA, HLA-PAI-1:6754G4G and HLA-DRB1*07*15, HLA-DRB1*16*16, HLA-DRB1*01*01 may be a predictor of the development of severe forms of influenza [11]. The gene discussed is HLA-DRB1; the disease is influenza.