Examples include the identification of IGHV3-53 and IGHV1-69 BCR clonotypes associated with neutralizing responses in COVID-19, the discovery of sigma-2 receptor (TMEM97) interactions with SARS-CoV-2 spike protein through transformer-based sequence embeddings, and the delineation of chromatin-accessibility motifs driving immune-cell differentiation (e.g., Pax5/Ebf1 and Spi1/Cebp) [27,30,33]. This evidence concerns the gene TMEM97 and COVID-19.