To address these potential limitations with three-dimensional modeling and to gain insight into the structure and function of type-P5 ATPases from the malaria parasite, Spf1, a rather well-characterized subtype-P5A ATPase [9], and ATP13A2, a rather well-characterized subtype-P5B ATPase [11], were used as templates to investigate the sequence and structural homologies of Plasmodium subtype-P5A ATPase (PlP5A), ATPase1, and ATPase3 from P. falciparum and P. relictum. Here, DNAH8 is linked to malaria.