Infection of CD14+ monocytes with African-lineage ZIKV typically induces a classical M1-skewed pro-inflammatory response, characterized by elevated expression of cytokines such as CXCL10 and IL-23A, whereas infection with Asian-lineage ZIKV tends to promote a non-classical M2-skewed immunosuppressive profile, driving IL-10 production and dampening inflammatory responses [113]. The gene discussed is IL10; the disease is infection.