The NF-κB pathway plays an important role in shaping the tumor microenvironment (TME), which broadly includes many different cell types, including immune cells, cancer-associated fibroblasts (CAF), tumor associated macrophages (TAM), endothelial cells, cytokines, and growth factors, with each cell type playing an individual role in tumor suppression or survival, providing strong evidence for targeting the NF-κB pathway as a means for cancer therapy. The gene discussed is NFKB1; the disease is neoplasm.