Looking more specifically at the association between NF-κB and cancer, activation of the pathway plays a significant role in tumor development and progression through mediation of cell survival, differentiation, and proliferation by regulating the expression of numerous biologically significant genes, including apoptosis regulators, stress-response genes, cytokines, chemokines, growth factors, and their receptors [4]. The gene discussed is NFKB1; the disease is cancer.