BCL2 and squamous cell carcinoma: Another more recent study used gene expression profiles in a mouse KB cell line, derived from an oral epidermoid carcinoma, which showed that thymoquinone downregulated the PI3K/AKT/mTOR pathway, in addition to downregulating BCL2 and upregulating BAX and downregulating pro-inflammatory cytokines [58], highlighting thymoquinone’s activity to repress the survival pathway while promoting apoptosis.