However, the future of AD management is reliant on using AI-based drug discovery approaches to find novel and more effective drug targets, combining agents effective on multi targets like anti-tau agents, anti-inflammatory agents, anti-Aβ agents, inhibitors of the enzyme involved in the disease pathology like cholinesterase’s, BACE1 inhibitors, and neurotrophic agents might give more convincing results. Here, BCHE is linked to Alzheimer disease.