MRAs have shown potential in influencing body mass, particularly in preventing weight gain and reducing visceral fat and are being investigated for their role in managing obesity-related metabolic complications by preventing white adipose tissue dysfunction and expansion, inducing the “browning” of white adipose tissue in animal models, a process that can increase energy expenditure and potentially reduce fat mass by increasing uncoupling protein 1 (UCP1) levels [29]. Here, UCP1 is linked to obesity due to melanocortin 4 receptor deficiency.