MYCN and neuroblastoma: Metabolic reprogramming has been identified as a hallmark of various malignancies [29,30,31], including neuroblastoma, and is an essential component of the c-Myc’s and N-MYC’s growth-promoting program, which stimulates cell growth and proliferation by enhancing glucose and glutamine uptake, energy production, and macromolecule biosynthesis [11,32,33,34].