The Nrf2/Keap1 pathway has extensive interactions with mitochondria, and in cancer cells, glycolysis/OXPHOS is closely linked to Bach1, in addition to Nrf2 and p21, and Keap1 is closely linked to mitochondrial biogenesis/mitophagy in metastatic CRC tumors, attempting to identify new drug targets [51]. Here, NFE2L2 is linked to colorectal carcinoma.