To this, we used a mouse model of acute amyloid toxicity, widely used by our group and others [74,75], in which AβOs are injected into the lateral ventricles of adult mice, inducing several key features of the disease, including oxidative stress, synapse loss, tau aggregation, and cognitive deficit [43,44,74,75] (Figure 7A). Here, MAPT is linked to Cognitive impairment.