ERBB2 and breast cancer: Oh et al. (2023) coated pre-formed Zr-based MOF nanoparticles (PCN-224) with GST-fused HER2- or EGFR-specific affibodies to form a protein–MOF hybrid system, creating a protective protein corona shield that minimized serum protein adsorption and enabled targeted delivery of camptothecin for synergistic PDT and chemotherapy in breast cancer models [70].