Extending to protein nanocage nanoparticle systems for intracellular drug delivery, Jun et al. (2022) displayed both tumor neutralizing factor-related apoptosis-inducing ligand (TRAIL) and EGFR-specific affibodies on pre-formed lumazine synthase protein cage nanoparticles post-assembly, synergistically inducing apoptosis and suppressing tumor growth in EGFR-overexpressing models through combined receptor targeting and death ligand activation [62]. This evidence concerns the gene EGFR and neoplasm.