According to the enrichment score, the top 20 pathway was sorted (Figure 4A), E. prostrata compounds mainly target pro-inflammatory cytokine pathways (IL-17, TNF), immune receptor-mediated signaling (B/T cell, lectin receptors), and infection-related inflammation pathways, while also intersecting with chronic inflammatory diseases (atherosclerosis, ROS signaling) and cancer-related inflammation. This evidence concerns the gene TNF and cancer.