STAT3 and heart failure: Among these, the top three proteins Signal Transducer and Activator of Transcription 3 (STAT3), Tumor Protein P53 (TP53), and Proto-oncogene Tyrosine-Protein Kinase Src (SRC) were selected for molecular docking and simulation analyses due to their high degree of centrality and well-established roles in heart failure (HF).