In a study, ganoderic acid (GA)-D affected several prostate cancer proteins in vitro that were later subjected to protein interaction network analysis in silico that revealed heat shock protein 90 kDa alpha member A1 (HSP90AA1), heat shock cognate 71 kDa protein (HSPA8), and exportin 1 (XPO1) as putative mechanistic components of GA-D’s anticancer effects [138]. The gene discussed is HSPA8; the disease is Familial prostate cancer.