Further integrated transcriptomic and metabolomic analysis revealed significant enrichment of the NF-κB signaling pathway, PI3K/Akt signaling pathway, JAK/STAT signaling pathway, phenylalanine, tyrosine and tryptophan biosynthesis, and arachidonic acid metabolism during the treatment of LN with PCPH. The gene discussed is ENTPD5; the disease is lobular neoplasia.