Dysregulation of this system is evident across primary dermatoses, including reduced AEA/2-AG and CB1/CB2 expression in atopic dermatitis, pro-inflammatory receptor–enzyme shifts in psoriasis, CB2–mitogen-activated protein kinase (MAPK)-driven lipogenesis in acne, and impaired re-epithelialization when CB2 tone is diminished during wound repair. The gene discussed is CNR2; the disease is acne.