To achieve tumor-specific delivery and coordinated activation of these pathways, we designed a multifunctional solid lipid nanoparticle (SLN) platform functionalized with PD-L1- and EGFR-targeting peptides, an ER-homing sequence, and a pH-labile poly(glutamic acid)–poly(ethylene glycol) (PGA–PEG) coating [5,7]. This evidence concerns the gene CD274 and neoplasm.