EGFR and colorectal carcinoma: Given that CT-26 cells recapitulate the limited immune infiltration characteristic of MSS CRC, with elevated PD-L1 and EGFR expression (Figure S3A), CLSM revealed that DiI-CB + miR/SLN-CSW rapidly associated with PD-L1 and EGFR within 1 h in CT-26 cells, mediated by W and C peptides.