CB + miR + R/SLN-CSW, with or without PGA, markedly increased intratumoral infiltration of CD4+ helper and CD8+ cytotoxic T cells (Figure 5E–H and Figure S8), a hallmark typically diminished in MSS CRC, while concomitantly reducing regulatory T cells expressing CD25 and FoxP3, and TAMs marked by F4/80 and CD206 (Figures S9–S11). Here, CD4 is linked to colorectal carcinoma.