MDK and glioblastoma: For brain tumors, polymer-locking fusogenic liposomes (Plofsomes) crossed the BBB and fused in ROS-rich glioblastoma (GBM) to deliver siRNA or CRISPR ribonucleoprotein complexes (RNPs), suppressing midkine to reduce temozolomide resistance with tumor-restricted activity [42], while echogenic liposomes served as cavitation nuclei for sonoporation in vivo, supporting a physical-trigger route adaptable to siRNA delivery [43].