For NSCLC perioperative care, an alginate hydrogel loaded with endoplasmic reticulum–modified liposomes co-delivering STAT3 siRNA and lidocaine induces tumor apoptosis, promotes M1 macrophages, decreases malignant pleural effusion, and relieves pain after a single application [37]. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.