This effect manifested as a lengthening of tear film breakup time, thickening of the corneal epithelium, an increase in the number of goblet cells in the conjunctiva, and a decrease in the expression of cytokeratin 10 (a sign of reduced squamous metaplasia, which is a characteristic pathological feature of dry eye syndrome) [81,83]. The gene discussed is KRT10; the disease is dry eye syndrome.