ABCG2 and colorectal adenocarcinoma: Furthermore, in Caco-2 cells, a cell line derived from human colorectal adenocarcinoma, Schrickx et al. demonstrated that OTA intracellular concentrations increased in the presence of Multidrug Resistance-associated Protein 2 (MRP2) and Breast Cancer Resistance Protein (BCRP) inhibitors, suggesting OTA to be a substrate for both [16].