CASP3 and neoplasm: While intratumor apoptosis was not high in any tumor group, JNP-4HPR and JNP-4HPR/TCZ significantly increased intratumor nuclear staining of the execution phase caspase-3, at ** p < 0.01 [Caspase-3 expression averaged 0.6% in the control group, 7.1% in the 4HPR-treated group, and 7.5% in the 4HPR-TCZ-treated group].