Enhanced phospho-γH2AX phosphorylated expression and reduced pRAS40 levels indicated DNA damage and functional AKT inhibition, even in the absence of changes in PI3K and mTOR phosphorylated protein (Figure 6D–F) confirm that treatment with SJ028 and SJ064 molecules inhibited AKT phosphorylation after 72 h of treatment in the T47-D tumor cell line (Figure 6G–I). This evidence concerns the gene PIK3CA and neoplasm.