TP53 and neoplasm: For example, T-47D cells harbor a TP53 L194F missense mutation, impairing p53 DNA-binding and its regulation of cell cycle arrest and apoptosis [34]; OVCAR-3 cells carry an TP53 R248Q mutation, which confers oncogenic properties and disrupts canonical tumor suppressor functions [35], while LNCaP cells present TP53 M160I mutation compromising p53 transcriptional activity [36].