GLI1 and pancreatic neoplasm: By characterizing the changes in glioma-associated oncogene 1 (Gli1) mRNA in tumor (biomarker) with an IDR model (inhibition of Kin, Table 2), the researchers were able to find that over 94% inhibition of tumoral Gli1 mRNA levels would be required to sufficiently inhibit (>90%) hedgehog-related tumor growth in mice bearing xenografts of human pancreatic tumors suggesting that tumoral Gli1 mRNA level could be a useful biomarker for predicting the antitumor effect of hedgehog inhibitors [83].