Abbreviations: EB = epidermolysis bullosa; AD = atopic dermatitis; CTCL = cutaneous T-cell lymphoma; ECM = extracellular matrix; APC = antigen-presenting cell; EV = extracellular vesicle; NP = nanoparticle; AMPs = antimicrobial peptides; NO = nitric oxide. Here, ADSL is linked to Alzheimer disease.