TP53 and non-small cell lung carcinoma: To that end, human NSCLC cell lines A549 and H1299 were employed to examine growth inhibition and apoptotic gene expression, while in vivo studies were carried out using mouse models of lung adenocarcinoma (induced by vinyl carbamate) in both p53 wild-type (p53wt/wt) and p53 mutant (p53wt/Ala135Val) backgrounds, as well as an SCC model induced by NTCU in female NIH Swiss mouse.