ABCC2 and cholestasis: The expressions of bile salt export pump (Bsep/BSEP; ABCB11), the main canalicular BS transporter, and multidrug resistance-associated protein 2 (Mrp2/Abcc2), which mediates the canalicular excretion of bilirubin, GSH, and glucuronidated/sulfated BSs [1], are impaired in LPS-induced cholestasis in rodents, at least in part, through transcriptional mechanisms [5].