ABCC3 and cholestasis: In addition, at the basolateral membrane, multidrug resistance-associated protein 3 (Mrp3/Abcc3) is adaptively upregulated in LPS-induced cholestasis [6], to extrude accumulated monovalent BSs (glyco- and tauro-conjugates) and divalent BSs (e.g., sulfo- and glucurono-conjugates) [7]; this reduces the concentration of potentially harmful BSs in hepatocytes by providing an alternative route of excretion via urine.