TYR and melanoma: Previous studies showed that UVA-irradiation induced α-MSH in HaCaT cells and that conditioned medium collected from UVA-irradiated HaCaT cells in the presence of 3-O-ethyl ascorbic acid or ectoine inhibited the expressions of melanogenic proteins and melanin and tyrosinase activity levels in B16F10 melanoma cells [30,31,59].