AKT1 and cancer: Moreover, IVM may induce immunogenic cell death in cancer cell lines by modulating several pathways, such as (1) the Wingless signaling (WNT)-T cell factor (TCF) [16,120,121], (2) Hippo factors [116,118], and (3) protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathways [16,122,123,124] as well as (4) inducing caspase-dependent apoptosis [116,118] and (5) p21-activated kinase 1 (PAK1)-mediated cytostatic autophagy [122,125,126,127].