Xie et al. developed Cu2O-MnO@PEG (CMP) nanomaterials, which directly induce cuproptosis in tumor cells and activate anti-tumor immune responses (enhancing antigen presentation, promoting CD8+ T cell responses, and inhibiting Treg cells), achieving tumor suppression and establishing long-term immune memory in combination with PD-L1 monoclonal antibodies, showing significant clinical translation potential [122]. The gene discussed is CD8A; the disease is neoplasm.