Cu can also function as a signaling molecule promoting tumor cell proliferation, invasion, and angiogenesis by activating or inhibiting signaling pathways such as phosphatidyqinositol-3 kinase/protein kinase B, hypoxia inducible factor 1 subunit alpha (HIF-1α), and nuclear factor kappa-B [13,14,15,16,17]. The gene discussed is HIF1A; the disease is neoplasm.