LOX and nonpapillary renal cell carcinoma: Xu et al. developed a nanodrug for clear cell renal cell carcinoma (ccRCC) by encapsulating lactate oxidase (LOx) into a ccRCC cell membrane-camouflaged CuO@Gd2O3 yolk–shell-like particle (mCGYL-LOx) to activate cuproptosis [100].