Ulcerative colitis rats were treated with 30 mg/kg cycloastragenol, and the gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumor necrosis factor (TNF)-α, and active caspase-3 were assessed. This evidence concerns the gene TNF and ulcerative colitis.