Chen et al. [23] investigated the ameliorative functions of cycloastragenol in cecal ligation and puncture (CLP)-induced systemic inflammation in sepsis and lipopolysaccharide (LPS)-mediated inflammatory response and the impact of a Toll-like receptor 4 (TLR4) pathway on the anti-inflammatory effects of cycloastragenol. The gene discussed is TLR4; the disease is Sepsis.