CD274 and neoplasm: Their cargo, aly-miR159a-3p, suppresses phospholipase C expression in recipient bacteria and promotes docosahexaenoic acid accumulation in tumor cells, which subsequently downregulates PD-L1 and significantly enhances the efficacy of anti-PD-L1 therapy—illustrating cross-domain regulation along a “plant vesicle–microbiota–tumor immunity” axis [75].