TCF7 and neoplasm: Related reviews and databases consistently highlight the plant miR-159–TCF7 axis as a key pathway: synthetic or plant-derived miR-159 downregulates TCF7, inhibits Wnt–MYC-related signaling, and suppresses tumor proliferation in mice while exerting relatively mild effects on normal mammary epithelial cells, indicating tumor selectivity for the combination of nucleic-acid cargo with plant vesicles [73].