The present study demonstrated that FCAE inhibited IL-1α, IL-17, MUC5AC, TNF-α, IL-6, CXCL1, CXCL2, and STAT3 phosphorylation, while reducing neutrophils, T cells, and B cells in the BALF and lungs of CSE/LPS-induced COPD mice. This evidence concerns the gene IL1A and chronic obstructive pulmonary disease.