After further adjustment for environmental covariates in Model 3, CRP (OR = 1.40, 95% CI: 1.03~1.90, p = 0.033) and SAA (OR = 1.36, 95% CI: 1.01~1.86, p = 0.048) levels remained significant, while O3 (p = 0.125) and GDM (p = 0.090) showed marginal significance. The gene discussed is CRP; the disease is gestational diabetes.