IL6 and systemic lupus erythematosus: A clinical trial reported in Indonesia has explored the use of a specific probiotic mixture (60% Lactobacillus helveticus, 20% Bifidobacterium infantis, and 20% Bifidobacterium bifidum) to reduce systemic IL-6 level and SLE disease activity and alter the composition and functions of gut microbiota [61]; yet, another trial conducted in Iran demonstrated that the daily regimen of 200 g of probiotic yogurt containing L. rhamnosus and B. bifidum for 13 weeks did not improve SLE disease activity index compared to untreated control [136].